Megamentin 375 375mg (6 capsules)

Megamentin 375 375mg (6 capsules)


375mg (6 capsules) of Augmentin Intas


Product Description

Megamentin 375 375mg (6 capsules).


Firstly, Megamentin 375 375mg is an oral drug manufactured by Intas Pharmaceuticals. This package contains two different drugs. The antibiotic amoxicillin and the beta-lactamase inhibitor potassium clavulanate work together to kill germs. The antibiotic is used to treat bacterial infections of the ear, sinuses, throat, lungs, urinary tract, skin, teeth, joints, and bones, among other places. It’s widely used to treat acne, a common skin ailment caused by bacteria.

Effects of the drug

Each chemical ingredient has a unique activity, allowing them to successfully destroy bacteria that cause diseases when used together. Amoxicillin is an antibiotic that stops germs from growing. This is accomplished by preventing the production of the protective layer required for bacteria to live. Potassium Clavulanate is responsible for lowering bacterial resistance and increasing Amoxicillin action.

How to take the drug

The required dosage of the drug is normally 750-1125mg per day, depending on the severity of the infection that you are trying to cure (2-3 tablets taken evenly spaced apart throughout the day). The drug is administered until all signs and symptoms of infection have vanished. If you stop taking the antibiotic too soon, some germs may still be present and develop resistance to it.

Augmentin is a combined antibiotic containing amoxicillin and clavulanic acid, with a broad spectrum of bactericidal action, resistant to beta-lactamase.

Furthermore, Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many Gram-positive and Gram-negative microorganisms. Amoxicillin is destroyed by beta-lactamase, and does not affect microorganisms that produce the enzyme. The mechanism of its action consists in inhibiting the biosynthesis-mucopeptides of the cell wall.

Clavulanic acid is a beta-lactamate structurally related to penicillins, which has the ability to inactivate a wide range of beta-lactamases. Beta-lactamases are produced by many Gram-positive play negative bacteria. The action of beta-lactamases can lead to the destruction of some antibacterial drugs even before their effects on pathogens. Clavulanic acid blocks the action of enzymes, restoring the sensitivity of bacteria to amoxicillin. In particular, it has a high activity for plasmid beta-lactamases, which are often associated with drug resistance, but less effective against type 1 chromosomal beta- lactamases.

The presence of clavulanic acid in the composition of Augmentin protects amoxicillin from the destructive action of beta-lactamases and expands its spectrum of antibacterial activity with the inclusion of microorganisms usually resistant to other penicillins and cephalosporins.



– hypersensitivity to beta-lactams, for example, kpenicillinam and cephalosporins
– jaundice or liver dysfunction, developed on a background of application of Augmentin or beta-lactam antibiotics
– Infectious mononucleosis


Interaction with other drugs

Also, It is not recommended to use Augmentin simultaneously with probenicid. Probenicid reduces tubular secretion of amoxicillin, and therefore, the simultaneous use of Augmentin and probenicida can lead to an increase in blood levels of amoxicillin.
The simultaneous use of allopurinol and Augmentin may increase the risk of allergic reactions. Data on the simultaneous application of allopurinol and Augmentin are currently not available.
Augmentin affects the intestinal flora and leads to a decrease in the reverse absorption, a decrease in the effectiveness of combined oral contraceptives.


The company Intas Pharmaceuticals produces an oral product called Megamentin 375. There are two drugs combined to create this product. These are Amoxicillin (an antibiotic) and Potassium Clavulanate (a beta-lactamase inhibitor) which work hand in hand to kill bacteria. The drug is commonly called Augmentin and is used to treat a wide variety of bacterial infections of the ear, sinus, throat, lung, urinary tract, skin, teeth, joints, and bones. It is widely used by many people to treat acne, which is a common skin condition caused by bacteria in the skin.



Each ingredient of the drug has a different action so that when working together they can effectively kill the bacteria that are the cause of infections. Amoxicillin is responsible for preventing the growth of bacteria. This is done by stopping the formation of the protective covering that is crucial for bacteria to be able to survive. Potassium Clavulanate is responsible for lowering the resistance of bacteria and enhancing the activity of Amoxicillin.



Depending on how bad the infection that you are trying to treat is, the required dosage of the drug is generally 750-1125mg a day (2-3 tablets should be taken at evenly spaced intervals throughout the day). It should be taken until all symptoms of infection are eradicated. Don’t stop taking the drug before the course has finished, otherwise some bacteria may still be present and may become resistant to the drugs effect.


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