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Tamoxifen 40mg 10 pills
40mg 10 pills of Tamoxifen citrate (Nolvadex) Sun Rise
Tamoxifen 40mg inhibits estrogen receptors, it has an estrogen-like effect. Tamoxifen is widely use in bodybuilding, because it prevents a number of side effects from most steroids. Therefore, the use of tamoxifen on PCT, especially for heavy courses is almost mandatory. Athletes believe that no victory is possible without Tamoxifen.
Tamoxifen citrate is a selective estrogen receptor modulator (SERM). This drug is widely use in the world’s medicine as a treatment against breast cancer. Instead that Tamoxifen citrate (Nolvadex) citrate SERM, bodybuilders take it also as an anti-estrogen and as a triphenylethylene. Selective Estrogen receptor modulators act as estrogen receptor agonists or antagonists in a tissue-selective manner. The main reason why it is use by athletes is that it will help prevent gynecomastia. Tamoxifen citrate does this by competing behind the receptor in the breast tissue, and bindings to it. This is the mean which act as tamoxifen and the estrogen receptor blockade of the breast tissue.
What is the effect of tamoxifen on the body?
Tamoxifen is a selective estrogen receptor modulator, which is a type of hormonal therapy (SERM). In breast cancer cells, the medication binds to hormone receptors (particular proteins). Once inside the cells, the medicine prevents the cancer from gaining access to the hormones it need to reproduce and thrive.
Those bodybuilders / athletes who take tamoxifen citrate as an anti-estrogen supplement remember that this is not the most effective auxiliary formulation, but it is given that safes. Tamoxifen citrate does not actually reduce estrogen in the human body, but it blocks estrogen from the estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
Uses of Tamoxifen
The use of Tamoxifen Citrate has a positive effect on the functionality of the immune system, and also on the lipid profile , Both on HDL and LDL. Tamoxifen citrate is select Often in therapy after the cycle. After taking this drug, hypogonadic and infertile men, there was a significant increase in serum levels of LH, FSH, and testosterone levels, as well. In fact, 20mgs of tamoxifen can possibly raise testosterone levels to about 150% of women engage in bodybuilding / athletes tend to take tamoxifen citrate in order to reduce the effect of endogenous estrogens on their own. This can reduce the concentration of body fat, especially in stubborn areas such as thighs and thighs.Side effects that can occur are: in women – hot flashes, irregular menstrual cycle and various complications with the reproductive system Tamoxifen citrate, in men – reduce profits.
On PСT, tamoxifen is recommend to combine with aromatase inhibitors, for example, Proviron. Tamoxifen is use in an amount of 20 mg daily, not more. Admission starts on the last week of the select steroid course. It is recommend to stop taking Tamoxifen after 2 weeks from the end of the steroid course. If Proviron is not taken, then Tamoxifen will be include a little later.
In the category of “anti-neoplastic agents,” TAMOXIFEN is mostly used to treat breast cancer. Infertility brought on by a woman’s inability to ovulate properly (produce and release an egg) is also treat with it. Breast cancer is a form of cancer that is trigger by the female sex hormone oestrogen in the breast cells.
Tamoxifen, a substance in TAMOXIFEN, is a “anti-oestrogen.” Oestrogen (the female sex hormone) is required by some kinds of breast cancer for growth. By inhibiting the effects of this oestrogen, TAMOXIFEN aids in the treatment of breast cancer. In addition, TAMOXIFEN is used to lower the chance of developing breast cancer in women based on their age and personal and family medical histories.
Utilize TAMOXIFEN as directed by your physician.
Uses of TAMOXIFEN
TAMOXIFEN contains Tamoxifen, which is an anti-oestrogen drug. It treats breast cancer that has spread to other parts of the body in men and women. TAMOXIFEN is also used to treat breast cancer in women who are earlier treat with surgery, radiation, and chemotherapy. It effectively treats infertility cause by failure in the ovulation (produce and release) process in women. Some types of breast cancers need oestrogen (female sex hormone) to grow. TAMOXIFEN blocks the effects of this oestrogen, thus helps in treating breast cancer. TAMOXIFEN is also use to reduce the risk of occurrence of breast cancer in women due to age, personal and family medical history.
Directions for Use
Side Effects of TAMOXIFEN
- Hot flashes
- Muscle aches
- Leg cramps
- Thinning of hair
- Numbness or tingling sensation
In-Depth Precautions and Warning
Also, Inform your doctor if you have any allergic reactions to TAMOXIFEN or other medications. Before starting TAMOXIFEN, let your doctor know if you have any medical history of liver or kidney diseases, heart diseases, high cholesterol levels, high blood pressure, diabetes, history of stroke or blood clot, receiving chemotherapy, and cataracts. TAMOXIFEN can affect the unborn baby when used in pregnancy. It may also have harmful effects on the breastfed infant when used by a lactating mother. Hence, TAMOXIFEN is not indicated for use in pregnancy and breastfeeding women. If you are using TAMOXIFEN, make sure to use reliable contraception forms to prevent pregnancy during the course. TAMOXIFEN can make you feel tired and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused. Avoid alcohol consumption while being treated with TAMOXIFEN. TAMOXIFEN is not recommend for children younger than two years of age.
Drug-Drug Interaction: TAMOXIFEN may interact with other drugs treating breast cancer (letrozole, anastrozole, exemestane), blood thinners (warfarin), anti-cancer drugs, antibiotics (rifampin), antidepressants (fluoxetine, paroxetine), fits medicines (carbamazepine, phenobarbital, phenytoin, primidone), anti-ulcer drugs (cimetidine), smoking cessation aids (bupropion), heart-related drugs (quinidine), and drugs treating hyperparathyroidism/overactive parathyroid gland (cinacalcet).
Drug-Food Interaction: Grapefruit and its juice may interact with TAMOXIFEN.
Drug-Disease Interaction: TAMOXIFEN should be used with caution in cases of liver or kidney diseases, heart diseases, high cholesterol levels, high blood pressure, diabetes, history of stroke or blood clot, receiving chemotherapy, and cataracts.
CONSULT YOUR DOCTOR
It is unsafe to consume alcohol while using TAMOXIFEN. Please consult your doctor for more information.
CONSULT YOUR DOCTOR
TAMOXIFEN is a pregnancy category D drug. It is unsafe to use TAMOXIFEN in pregnancy and can have harmful effects on the unborn baby. Use reliable forms of contraception to prevent pregnancy while using TAMOXIFEN.
CONSULT YOUR DOCTOR
TAMOXIFEN is not recommended to use during breastfeeding since it may be unsafe for the breastfed infant. Please seek medical advice if you are a nursing mother before starting TAMOXIFEN.
CONSULT YOUR DOCTOR
TAMOXIFEN causes tiredness and may affect your ability to drive. Do not drive or operate machinery if you experience any unmanageable side effects with TAMOXIFEN.
Please let your doctor know if you have any history of liver diseases or hepatic impairment before starting TAMOXIFEN.
Please let your doctor know if you have any history of kidney diseases before starting TAMOXIFEN.
Diet & Lifestyle Advise
- Take the medication as direct by the doctor and at regular intervals.
- Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
- Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
- Avoid grilled meat, red meat, saturate fat is in animal products, milk and dairy products.
- Exercise regularly to lose weight as obesity is also consider a risk factor for prostate cancer.
- Eat at regular intervals.
- Keep your weight under control with BMI of 19.5-24.9.
- Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
- Your doctor may advise regular physical exams and mammograms.
- Self-examine your breasts to check for any lumps monthly while using TAMOXIFEN.
- Your doctor may also advise liver function tests to monitor your liver health.
- TAMOXIFEN may interfere with specific tests like thyroid tests. Hence, it is important to inform your doctor or laboratory staff that you use TAMOXIFEN before undergoing any medical examinations.
Furthermore, Breast cancer is a type of cancer that develops in breast cells stimulate by a female sex hormone called oestrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes, a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplain change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm.
How does tamoxifen work in the body?
Tamoxifen belongs to a class of medications known as selective estrogen receptor modulators (SERMs). It works in two ways — it lowers estrogen activity in some areas of the body and acts similarly to estrogen in other areas.
For example, tamoxifen prevents estrogen from attaching to receptors in the breast tissue, slowing down the growth of cancer cells. At the same time, tamoxifen acts like estrogen does on the bones, helping to lower the risk of bone-related side effects in some people (more detail on this later).
How do people typically take tamoxifen?
Tamoxifen comes as an inexpensive generic tablet available in 10 mg and 20 mg strengths. It’s also available as a brand-name oral liquid called Soltamox for people who have trouble swallowing pills. However, the liquid is much more expensive than the tablets because it currently has no generic alternative.
Tamoxifen is FDA-approved to treat ER+ breast cancer at both early and advanced stages, including metastatic breast cancer — cancer that started in the breast but has spread to other parts of the body. It’s also approved to help prevent breast cancer in high-risk people, such as those with a strong family history of breast cancer and those with certain genetic changes.
For people with non-metastatic breast cancer, the recommended dose is 20 mg once a day for 5 years after a mastectomy — surgery that removes part or all of the breast(s). However, some sources suggest continuing the medication for a total of 10 years may help lower the risk of breast cancer recurrence (when cancer returns after being gone).
For people with metastatic breast cancer, the recommend dose is 20 mg to 40 mg per day for at least 5 years. The 20 mg dose can be taken once a day, but the 40 mg dose should be taken as 20 mg twice a day (morning and evening). Some studies suggest taking 40 mg per day may be no more effective than taking 20 mg per day, but healthcare providers may still choose to prescribe the higher dose for some people.
People taking tamoxifen to prevent breast cancer are recommend to take 20 mg daily for 5 years.
Who should and shouldn’t take tamoxifen?
As mentioned, tamoxifen is FDA-approve to treat ER+ breast cancer in adults and lower the risk of breast cancer in women who fall into certain categories. It can be used before or after a person goes through menopause, but it is not FDA-approved for cancer in children.
While a healthcare provider who specializes in treating children with cancer may prescribe tamoxifen for a child, this is considered an off-label use. In this case, the strength, dose, and length of treatment may be different than what’s typical, so please follow your provider’s instructions very carefully.
Unfortunately, tamoxifen may not be safe for everyone. There are some times where this medication may not be right for you, including if you:
Are pregnant or planning to become pregnant (tamoxifen can harm your unborn baby)
Are nursing (tamoxifen can pass through your milk to the baby)
Have a history of serious blood clots or stroke
Take warfarin (a blood thinner medication) for blood clot prevention
Take estrogen-based medications, such as birth control or menopause medications
Are under the age of 35
Are currently taking aromatase inhibitors (a different group of breast cancer medications). It’s important to note that switching between these medications and tamoxifen is OK. You just shouldn’t take them both at the same time.
Some of these restrictions may only apply to people taking tamoxifen to lower breast cancer risk. If you have breast cancer and you fall into any of these categories, you and your healthcare provider will discuss whether the benefits of taking tamoxifen outweigh the potential risks.
What happens when you stop taking tamoxifen?
One concern when a person finishes tamoxifen is the possibility of breast cancer recurrence. After your tamoxifen treatment is finished, your healthcare provider will make a post-treatment plan with you that will include follow-up visits and screening tests. This plan can help catch breast cancer recurrence early.
Screening tests that may be ordered include:
Mammograms to check for breast cancer
Pelvic exams to detect uterine cancer — a possible long-term risk when taking tamoxifen
Bone density tests to screen for changes in your bone health
Blood tests or x-rays — typically only needed if you’re having unusual symptoms
What side effects are associated with tamoxifen?
Because tamoxifen affects how estrogen works in the body, some of its side effects are cause by this changing estrogen activity. Some common side effects of tamoxifen to be aware of include:
Nausea or vomiting
Swelling from retaining fluid
Irregular or no monthly bleeding
Muscle, joint, or bone pain
Weakness or tiredness
Are there any health risks associated with taking tamoxifen?
Aside from the common side effects, tamoxifen can cause some more serious health problems that you should be aware of. They include:
Higher risk of blood clots
Eye problems, such as cataracts
Higher risk of uterine cancer
Bone loss in people who haven’t gone through menopause
Call 911 or seek immediate medical care if you experience any of the following:
Leg swelling or tenderness, leg that’s red or warm to touch, shortness of breath, chest pain (possible signs of a blood clot)
Unusual monthly bleeding or severe pains around the hips and groin (possible warning signs of uterine cancer)
What are the long-term effects of taking tamoxifen?
As discusse above, tamoxifen works by blocking estrogen activity in the breasts. However, it can have the opposite effect on the internal reproductive organs. Researchers believe this may contribute to other types of cancer.
For example, some studies have that people who take tamoxifen long-term are more likely to develop cancer in the lining of the uterus — known as endometrial cancer — or other uterine tumors.
Tamoxifen can also affect bone density — a measure of the strength of the bone. But your risk of this side effect may depend on whether you’ve gone through menopause yet.
One study follow a group of people who hadn’t gone through menopause yet and were taking tamoxifen. The study show that tamoxifen cause more bone loss in people who continued to menstruate during and after tamoxifen treatment. However, it actually helped to prevent bone loss in those who stopped menstruating during treatment.
Another study of people who gone through menopause and took tamoxifen found that it helped stop bone loss in the spine. It’s important to note that neither of these studies looked at whether these people had a higher or lower risk of broken bones because of tamoxifen.
Researchers have also found a link between tamoxifen and eye problems. A study of over 2,600 people who took tamoxifen found that the medication raised their risk of developing cataracts — a serious eye condition that can cause blindness if not treated. This risk rises the longer you take tamoxifen, with the highest risk being in people who took this medication for 5 years or more.
Lastly, studies have shown that tamoxifen can raise your risk for a pulmonary embolism — a life-threatening condition where a blood clot forms and travels to the lungs. If you have a history of blood clots, make sure your healthcare provider is aware of this before you start taking tamoxifen.