Megamentinc 625 625mg (6 capsules)

Megamentinc 625 625mg (6 capsules)

$12.00

625mg (6 capsules) of Augmentin Intas

Product Description

Megamentinc 625 625mg (6 capsules).

Firstly, Augmentin is a combined antibiotic containing amoxicillin and clavulanic acid, with a broad spectrum of bactericidal action, resistant to beta-lactamase. Buy Megamentinc 625 online in USA .

Form of issue

Tablets, film-coated

Composition

1 tablet (625 mg) contains amoxicillin (as trihydrate) 500 mg and clavulanic acid (as the potassium salt) 125 mg

Packaging

15 pcs.

Pharmachologic effect

Megamentinc 625 is a broad-spectrum antibiotic; contains semi-synthetic penicillin amoxicillin and b-lactamase inhibitor clavulanic acid. Clavulanic acid inhibits the majority of clinically significant b-lactamases (types 2, 3, 4 and 5 according to the Richmond Sykes classification) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive for Type I β-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.
Similarly, this combination provides a high bactericidal activity of Megamentinc 625 (including against strains of microorganisms resistant to amoxicillin). Clavulanic acid, having a higher affinity for b-lactamase than amoxicillin, forms a stable deactivated complex with the enzyme, preventing the enzymatic degradation of amoxicillin by the action of b-lactamases.
Thus, Megamentinc 625 acts bactericidal on a wide range of gram-positive and gram-negative bacteria (including strains that have become resistant to beta-lactam antibiotics due to the production of b-lactamases).

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the preparation:

  • infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, zaglugal abscess, tonsillitis, pharyngitis);
  • infections of the lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);
  • urinary tract infections;
  • gynecological infections;
  • skin and soft tissue infections;
  • infections of bones and joints;
  • biliary tract infections (cholecystitis, cholangitis); .

Contraindications Megamentinc 625

– Cholestatic jaundice or liver dysfunction caused by taking an amoxicillin / clavulanic acid in an anamnesis;
– Hypersensitivity to amoxicillin, clavulanic acid or penicillins.
With caution should prescribe the drug for allergic reactions to cephalosporins and pseudomembranous colitis in history, liver failure, severe impairment of kidney function.
Due to the fact that a large number of patients with infectious mononucleosis and lymphocytic leukemia who received ampicillin, observed the appearance of erythematous rash, the use of ampicillin antibiotics in such patients is not recommended.

Application in pregnancy and lactation

Amoxicillin and clavulanic acid penetrate in small amounts into breast milk.
Amoxiclav can be used in pregnancy if the expected benefit to the mother exceeds the potential risk to the fetus.

Dosing and Administration Megamentinc 625

Also, Adults and children over 12 years of age (or with a body weight of more than 40 kg) with a mild or moderate infection are prescribed 1 tab. 375 mg every 8 hours, in case of severe infection and respiratory tract infections – 1 tab. 625 mg every 8 hours or 1 tab. 1000 mg every 12 hours.
The drug in the form of coated tablets is not prescribed for children under 12 years of age (with a body weight of less than 40 kg).
The maximum daily dose of clavulanic acid is 600 mg for adults, 10 mg / kg for children.
The maximum daily dose of amoxicillin is 6 g for adults and 45 mg / kg for children.
The course of treatment is 5-14 days. The duration of the course of treatment is determined by the attending physician. Treatment should not last more than 14 days without a second medical examination.
For odontogenic infections, 1 tablet is prescribed. 375 mg every 8 hours for 5 days.

Side effects of Megamentinc 625

Also, On the part of the digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely – transient increase in the activity of liver enzymes (ALT, AST), liver dysfunction; in isolated cases – cholestatic jaundice, hepatitis, pseudomembranous colitis.
Allergic reactions: erythematous rash, itching, urticaria; rarely – multiforme exudative erythema, angioedema, anaphylactic shock; in isolated cases – exfoliative dermatitis, Stevens-Johnson syndrome.
Other: rarely – development of superinfection, candidiasis.

Special instructions

Then, at course treatment it is necessary to control the function of hematopoiesis, liver and kidneys.
Patients with severe impairment of renal function require adequate correction of the dosing regimen or an increase in the intervals between dosing.
Also, to reduce the risk of adverse reactions from the gastrointestinal tract, you should take the drug while eating.
When using Megamentinc 625, a false positive reaction is possible when determining the glucose level in urine using a Benedict reagent or a Felling solution (it is recommended to use enzymatic reactions with glucose oxidase).
Simultaneous administration with disulfiram should be avoided.

Megamentinc 625 Interactions

Furthermore, With the simultaneous use of Megamentinc 625 and indirect anticoagulants, an increase in prothrombin time is noted. Therefore, this combination is appointed with caution.
With the simultaneous use of Megamentinc 625 and allopurinol, the risk of developing side effects such as exanthema increases.
With the simultaneous use of Megamentinc 625 enhances the toxicity of methotrexate.
The combination of Amoxicillin and rifampicin is antagonistic (there is a mutual weakening of the antibacterial effect).
Amoxiclav should not be used concomitantly with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible decrease in the effectiveness of Megamentinc 625.
With simultaneous use, Megamentinc 625 reduces the effectiveness of oral contraceptives.

Secondly, Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many Gram-positive and Gram-negative microorganisms. Amoxicillin is destroyed by beta-lactamase, and does not affect microorganisms that produce the enzyme. The mechanism of its action consists in inhibiting the biosynthesis-mucopeptides of the cell wall.

Also, Clavulanic acid is a beta-lactamate structurally related to penicillins, which has the ability to inactivate a wide range of beta-lactamases. Beta-lactamases are produced by many Gram-positive play negative bacteria. The action of beta-lactamases can lead to the destruction of some antibacterial drugs even before their effects on pathogens. Clavulanic acid blocks the action of enzymes, restoring the sensitivity of bacteria to amoxicillin. In particular, it has a high activity for plasmid beta-lactamases, which are often associated with drug resistance, but less effective against type 1 chromosomal beta- lactamases.

Thirdly, the presence of clavulanic acid in the composition of Augmentin protects amoxicillin from the destructive action of beta-lactamases and expands its spectrum of antibacterial activity with the inclusion of microorganisms usually resistant to other penicillins and cephalosporins.

Contraindications

– hypersensitivity to beta-lactams, for example, kpenicillinam and cephalosporins
– jaundice or liver dysfunction, developed on a background of application of Augmentin or beta-lactam antibiotics
– Infectious mononucleosis

Interaction with other drugs

Also, It is not recommended to use Augmentin simultaneously with probenicid. Probenicid reduces tubular secretion of amoxicillin, and therefore, the simultaneous use of Augmentin and probenicida can lead to an increase in blood levels of amoxicillin.
The simultaneous use of allopurinol and Augmentin may increase the risk of allergic reactions. Data on the simultaneous application of allopurinol and Augmentin are currently not available.
Augmentin affects the intestinal flora and leads to a decrease in the reverse absorption, a decrease in the effectiveness of combined oral contraceptives.

USES OF MEGAMENTIN 625MG TABLET

  • Treats bacterial infection

HOW MEGAMENTIN 625MG TABLET WORKS

MEGAMENTIN 625MG TABLET helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of the integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.

DIRECTIONS FOR USE

Film-coated tablets:

Take MEGAMENTIN 625MG TABLET as advised by your physician. Swallow the tablet with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Dispersible tablets:

Take MEGAMENTIN 625MG TABLET as advised by your physician. Place the tablet in the mouth, let it dissolve, and then swallow. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Powder for oral suspension (in sachets):

Take MEGAMENTIN 625MG TABLET as advised by your physician. Open the sachet, mix the contents thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF MEGAMENTIN 625MG TABLET

COMMON

  • Diarrhoea
  • Thrush (fungal infection in the vagina, skin folds, or mouth)
  • Nausea
  • Vomiting

UNCOMMON

  • Skin rash
  • Itching
  • Raised itchy rash (hives)
  • Indigestion
  • Dizziness
  • Headache

RARE

  • Erythema multiforme (a skin rash that looks like small targets)
  • Reversible leucopoenia including neutropenia (deficiency of white blood cells)
  • Reversible thrombocytopenia (deficiency of blood platelets)

Stop taking MEGAMENTIN 625MG TABLET and contact your doctor if you experience any of the following side effects:

  • Signs of allergic reactions on the skin such as skin rash
  • Signs of vasculitis (inflammation of blood vessels) such as raised red or purple spots on the skin
  • Signs of allergic reactions such as fever, joint pain, swollen glands in the neck, armpit or groin
  • Signs of angioedema such as swelling on the face or mouth resulting in difficulty in breathing, or collapse
  • Inflammation of the liver (hepatitis)
  • Jaundice
  • Inflammation of kidney tubes
  • Prolongation of blood clotting time
  • Convulsions
  • Black tongue with hairy look
  • Staining of teeth

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Nausea and vomiting:

Try to take MEGAMENTIN 625MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

PREGNANCY

MEGAMENTIN 625MG TABLET should be used with caution in pregnant women only if it is considered clearly necessary. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

BREASTFEEDING

MEGAMENTIN 625MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

DRIVING AND USING MACHINES

Do not drive or operate machines while taking if you feel unwell.

KIDNEY

MEGAMENTIN 625MG TABLET should be used with caution in patients with renal impairment or kidney problems. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

LIVER

MEGAMENTIN 625MG TABLET is not recommended for use if you have if you ever had liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. It should be used with caution in patients with hepatic impairment or liver problems. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

ALLERGY

Do not take MEGAMENTIN 625MG TABLET if you are allergic to amoxicillin, clavulanic acid, penicillin, any antibiotic, or any other ingredients of this medicine. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

OTHERS

Before taking MEGAMENTIN 625MG TABLET, inform your doctor if you:

  • Have glandular fever
  • Are unable to pass water properly

Use in Paediatrics:

MEGAMENTIN 625MG TABLET should be used with caution in children (below 12 years). Consult your doctor before taking MEGAMENTIN 625MG TABLET.

Use in Geriatrics:

MEGAMENTIN 625MG TABLET should be used with caution in elderly patients (above 50 years). Consult your doctor before taking MEGAMENTIN 625MG TABLET.

INTERACTIONS

A. Drug-Drug Interactions

Before taking MEGAMENTIN 625MG TABLET, inform your doctor, if you are taking any of the following medicine:

  • Allopurinol, probenecid (medicine use to treat gout)
  • Warfarin (medicine use to delay blood clotting)
  • Methotrexate (medicine use to treat rheumatic diseases or certain cancers)
  • Mycophenolate mofetil (a medicine used to prevent the organ rejection after organ transplant)
  • Contraceptives (medicines use to prevent conception)

Overdosage:

If you or anyone else accidentally takes too much of MEGAMENTIN 625MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation).

SYNOPSIS

Drug : Amoxicillin, Clavulanic Acid
Pharmacological Category : Antibiotics
Therapeutic Indication : Bacterial infections
Dosage Forms : Tablet, Dispersible Tablet, Capsule, Sachet

MORE INFORMATION

  • Keep the medicine out of reach of children
  • Store MEGAMENTIN 625MG TABLET at a temperature not exceeding 30°C
  • How to use:
    • Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Megamentin -625 Tablet is to be taken with food.This will help to avoid stomach upset.

    How it works:

    • Megamentin -625 Tablet is a combination of two medicines: Amoxicillin and Clavulanic Acid. Amoxicillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Clavulanic Acid is a beta-lactamase inhibitor which blocks the action of enzymes produced by bacteria to inactivate amoxicillin. Addition of Clavulanic Acid reduces resistance and enhances the activity of Amoxicillin against bacteria.

FAQs ABOUT MEGAMENTIN 625MG TABLET

What MEGAMENTIN 625MG TABLET is used for?

MEGAMENTIN 625MG TABLET is used for treating bacterial infections including middle ear & sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin & soft tissue infections such as dental infections, bone & joint infections, septic abortion (any abortion complicated by uterine infection), and abdominal infections.

What happens if you take more MEGAMENTIN 625MG TABLET than your required dose?

If you or anyone else accidentally takes too much of MEGAMENTIN 625MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation).

What side effects are seen with MEGAMENTIN 625MG TABLET?

The common side effects associate with the use of MEGAMENTIN 625MG TABLET are diarrhoea, thrush (fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.

Who should avoid taking MEGAMENTIN 625MG TABLET?

Do not take MEGAMENTIN 625MG TABLET if you are allergic to amoxicillin, clavulanic acid, penicillin, or any antibiotic. It is not recommend for use if you have liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate.

Is MEGAMENTIN 625MG TABLET safe to use in children?

MEGAMENTIN 625MG TABLET should be use with caution in children (below 12 years). Children (age 6 years or below) should be treated with oral suspension or sachets containing amoxicillin and clavulanic acid. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

How does MEGAMENTIN 625MG TABLET work?

MEGAMENTIN 625MG TABLET helps in treating bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.

What is the method of taking MEGAMENTIN 625MG TABLET?

Film-coated tablets:

Take MEGAMENTIN 625MG TABLET as advised by your physician. Swallow the tablet with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Dispersible tablets:

Take MEGAMENTIN 625MG TABLET as advised by your physician. Place the tablet in the mouth, let it dissolve, and then swallow. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Powder for oral suspension (in sachets):

Take MEGAMENTIN 625MG TABLET as advised by your physician. Open the sachet, mix the contents thoroughly in a glass of water, and swallow the mixture immediately. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

What if I forget to take MEGAMENTIN 625MG TABLET dose?

If you forgot to take MEGAMENTIN 625MG TABLET dose, take it as early as possible. Avoid taking the next dose too soon. Wait for about 4 hours before taking the scheduled next dose. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

When to stop taking MEGAMENTIN 625MG TABLET?

Do not stop taking MEGAMENTIN 625MG TABLET without thoroughly discussing it with your doctor until the treatment course is completed, even if you start feeling better. This is because if some bacteria survive due to incomplete medication, they may relapse into the infection.

Is MEGAMENTIN 625MG TABLET safe to use in liver patients?

MEGAMENTIN 625MG TABLET is not recommended for use if you have liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. It should be used with caution in patients with hepatic impairment or liver problems. Consult your doctor before taking MEGAMENTIN 625MG TABLET.

REFERENCES

1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 723.

2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. December 2021. [Assessed on 26th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/

3. Lek Pharmaceuticals d.d. Health Products Regulatory Authority (HPRA). [Revised in December 2014] [Assessed on 26th October 2022] https://www.hpra.ie/img/uploaded/swedocuments/pl-clean-2157753-09062015140435-635694554758986250.pdf

4. GSK group of companies. Augmentin. [Revised in December 2017] [Assessed on 26th October 2022] https://gskpro.com/content/dam/global/hcpportal/en_MU/PI/Clavulin-228.5mg5ml-Susp-GDS-24.pdf

5. Macleods Pharmaceuticals Ltd. Polyclav DS Tab. [Assessed on 26th October 2022] https://www.macleodspharma.com/products/

6. Micro Labs Ltd. Erox CV Dispersible Tablets. [Assessed on 26th October 2022] http://www.microlabsltd.com/elibrary/node/2192

USEFUL DIAGNOSTIC TESTS

  • Blood tests
  • Urine tests
  • Liver function test

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